Spatial Segregation of γ-Secretase and Substrates in DistinctMembraneDomains
نویسندگان
چکیده
منابع مشابه
Spatial Segregation of -Secretase and Substrates in Distinct Membrane Domains*
-Secretase facilitates the regulated intramembrane proteolysis of select type I membrane proteins that play diverse physiological roles in multiple cell types and tissue. In this study, we used biochemical approaches to examine the distribution of amyloid precursor protein (APP) and several additional -secretase substrates in membrane microdomains. We report that APP C-terminal fragments (CTFs)...
متن کاملBioinformatic Study of γ-Secretase and its Substrates
Bioinformatic Study of γ-Secretase and its Substrates
متن کاملCaveolin-1 regulates γ-secretase-mediated AβPP processing by modulating spatial distribution of γ-secretase in membrane.
Amyloidogenic processing of amyloid-β precursor protein (AβPP) is associated with cholesterol- and sphingolipid-rich lipid rafts. Caveolin-1, a raft-residing protein, has been implicated in the pathogenesis of Alzheimer's disease. To determine the role of caveolin-1 in governing γ-secretase-mediated AβPP proteolysis, cellular γ-secretase activity was assessed in response to alteration in caveol...
متن کاملSpatial Segregation in Demography: A Short Review
Abstract. Spatial has always been an inherent component of demography, and demographic processes are inherently spatiotemporal. Recognizing the importance of spatial in general and spatial segregation in particular in demographic analysis has created new positions in demography and its conceptual and analytical frameworks. The notion of spatial segregation refers to the distribution of social...
متن کاملProteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
The presenilin/gamma-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins from the membrane and also mediate the secretion of amyloid-beta protein (Abeta) has made modulation of gamma-secretase activity a therapeutic goal for cancer and Alzheim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m503570200